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ORIGINAL ARTICLE
Year : 2017  |  Volume : 3  |  Issue : 3  |  Page : 12-17

The effects of different compatibilities of Qing'e formula on scopolamine-induced learning and memory impairment in the mouse


1 School of Pharmacy, Lanzhou University, Lanzhou 730000, China
2 The MOE Key Laboratory for Standardization of Chinese Medicines and the Key Laboratory for Pharmacology of Compound Chinese Medicine of Shanghai, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine; Research Center for Traditional Chinese Medicine of Complexity System, Shanghai University of Traditional Chinese Medicine, Shanghai 201302, China

Correspondence Address:
Fang-Di Hu
School of Pharmacy, Lanzhou University, Lanzhou 730000
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/wjtcm.wjtcm_8_17

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Background: The Qing'e formula (QEF) is a well-known traditional Chinese prescription that has been clinically employed for treatment of bone disease for hundreds of years. Objective: The present study aims to observe the effects of different compatibilities of QEF on the scopolamine-induced learning and memory impairment in the mouse, and further to explore its action mechanisms and compatibility rationality. Materials and Methods: The learning and memory alterations in the mouse were evaluated using the step-down test and Morris water maze (MWM) test; the acetylcholinesterase (AChE) activity and brain-derived neurotrophic factor (BDNF) expression in the hippocampus were measured using colorimetric method or immunohistochemistry. Results: The results showed that different compatibilities of QEF significantly prolonged latency in the step-down test, shortened escape latency in the navigation test, increased the percentage of residence time, and the percentage of swimming distance in the target quadrant in the probe trial session. In addition, our results also found that different compatibilities of QEF remarkably inhibited AChE activity and increased BDNF expression in the hippocampus of mice. What's more, the group after being treated with whole recipe (QF) showed the highest level of improvement. Conclusions: These findings not only suggest that QEF may effectively ameliorate cognitive deficits through inhibiting AChE activity and increasing BDNF expression in the hippocampus but also elucidate the rationality of QEF.


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