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ORIGINAL ARTICLE
Year : 2018  |  Volume : 4  |  Issue : 2  |  Page : 54-61

Using the Box–Behnken response surface method to optimize the preparation and characterization of lavender and fennel volatile oil β-cyclodextrin form inclusion complex


1 The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Jiangxi, China
2 Chinese Medicine Research Institute, Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences, Dongzhimen, Dongcheng District, Beijing 100700, China
3 Basic Medical College, Xinjiang Medical University, Xinjiang, Wulumuqi 830011, China

Correspondence Address:
Dong-Xun Li
The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, 56 Yangming Road, Jiangxi, Nanchang 330006
China
Guo-Song Zhang
The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, 56 Yangming Road, Jiangxi, Nanchang 330006
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/wjtcm.wjtcm_9_18

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Objective: The objective of this study is to study the best inclusion technology of Lavender- and fennel-mixed volatile oil by beta-cyclodextrin (β-CD) and characterize the final product thereafter. Methods: Using the saturated water solution method, the volatile β-CD inclusion complex was produced. The effect of volatile oil weight ratio, inclusion temperature and inclusion time on the inclusive quality was studied by measuring the yield of inclusion and inclusion rate of volatile oil as evaluation indexes. The preparation method of inclusion complex was then optimized by the Box-Behnken response surface method. The inclusion complex was characterized by ultraviolet spectrophotometry, thin-layer chromatography, thermogravimetry and differential thermal analysis, and the microscopic imaging method. Results: The optimized conditions were the weight ratio of β-CD to volatile oil was 8.13:1 (g/ml). The inclusion temperature was 44°C. The inclusion time was 1 h. Conclusion: We were able to produce an inclusion complex with high inclusion rate of volatile oil and high yield of inclusion using the preparation method mentioned above. Furthermore, the method can also improve the stability of volatile oil in abnormal savda munziq. This study can provide a good reference for the development of new preparations.


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