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ORIGINAL ARTICLE
Year : 2018  |  Volume : 4  |  Issue : 4  |  Page : 137-146

Exploring the pathways and targets of Shexiang Baoxin pill for coronary heart disease through a network pharmacology approach


1 State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, Qinghai; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China
2 State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, Qinghai, China
3 Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, China
4 Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China
5 Department of Clinical Science 2, Faculty of Medicine and Dentistry, University of Bergen, 5009, Norway
6 Department of Phytochemistry, School of Pharmacy, Second Military Medical University; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China

Correspondence Address:
Hong-Lin Li
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237
China
Wei-Dong Zhang
School of Pharmacy, Second Military Medical University 325#, Guohe Road, Shanghai 200433
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/wjtcm.wjtcm_18_18

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Objective: To investigate the network pharmacology of Shexiang Baoxin pill (SBP) and systematically analyze the mechanisms of SBP. Methods: In this study, we excavated all the targets of 26 constituents of SBP which were identified in rat plasma though literature mining and target calculation (reverse docking and similarity search) and analyzed the multiple pharmacology actions of SBP comprehensively through a network pharmacology approach. Results: In the end, a total of 330 Homo sapiens targets were identified for 26 blood constituents of SBP. Moreover, the pathway enrichment analysis found that these targets mapped into 171 KEGG pathways and 31 of which were more enriched. Among these identified pathways, 3 pathways were selected for analyzing the mechanisms of SBP for treating coronary heart disease. Conclusion: This study systematically illustrated the mechanisms of the SBP by analyzing the corresponding “drug-target-pathway-disease” interaction network.


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