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REVIEW ARTICLE
Year : 2019  |  Volume : 5  |  Issue : 2  |  Page : 122-130

Research progress on the intervening effects of active components of Chinese herbs on amyloid-beta-induced injury of neural cells


1 Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica; Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues; Faculty of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
2 Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine; Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Nanning, Guangxi, China

Correspondence Address:
Er-Wei Hao
Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine, Nanning, Guangxi
China
Jia-Gang Deng
Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine, Nanning, Guangxi
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/wjtcm.wjtcm_11_19

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Alzheimer's disease is a common clinical central nervous system degenerative disease. From 1906, it has not yet been clearly revealed the pathogenesis, and there are no clinically safe and effective drugs. Amyloid-beta (Aβ) cascade reaction theory is currently recognized as the pathogenesis. Aβ deposition of neurotoxicity is an important part of the pathogenesis. There are Aβ-induced inflammation of the central nervous and oxidative stress-induced apoptosis induced by a variety of ways leading to neuronal dysfunction and death. This article summarizes the active ingredients of traditional Chinese medicine that has a protective effect on Aβ toxicity in recent years. Traditional Chinese medicine mainly through the antiapoptosis, antioxidation, and anti-inflammatory reduces Aβ production and deposition of Aβ on the protection of nerve cell injury.


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