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ORIGINAL ARTICLE
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Traditional Chinese medicine syndromes distribution in colorectal cancer and its association with western medicine treatment and clinical laboratory indicators


1 Research Center for Traditional Chinese Medicine Complexity System, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2 Research Center for Traditional Chinese Medicine Complexity System, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine; Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
3 Department of Anorectal, Nanjing Hospital of Traditional Chinese Medicine, Nanjing, China
4 Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
5 Department of Integrated Traditional Chinese and Western Medicine, Tumour Hospital Affiliated to Fudan University, Shanghai, China
6 Department of Proctology, Nanjing Hospital of Traditional Chinese Medicine, Nanjing, China

Correspondence Address:
Shi-Bing Su,
Research Center for Traditional Chinese Medicine Complexity System, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203
China
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/wjtcm.wjtcm_26_18

Objective: The objective of the study is to explore the traditional Chinese medicine (TCM) syndrome distribution in colorectal cancer (CRC) and its correlation with treatment methods and clinical laboratory indicators. Materials and Methods: Using the CRC cases report form of TCM, 760 CRC patients with TCM four diagnosis information, western medicine treatment information and clinical laboratory indicators were collected, and TCM syndromes distribution in CRC were summarized. The correlation between TCM syndrome type and western medicine treatments, clinical laboratory indicators such as liver and kidney function, immune function, and tumor biomarkers was analyzed. Results: In 760 cases of CRC, Spleen deficiency syndrome (SDS, 25%), liver and kidney Yin deficiency syndrome (LKYDS, 13%), LKYDS-SDS, 12%, spleen deficient Qi stagnation syndrome (SDQSS, 10%), and damp heat syndrome (DHS, 9%) were more common TCM syndrome types. LKYDS, SDS, LKYDS-SDS, and SDQSS were significantly distributed under different treatment methods (P < 0.001). There was no statistically significant difference in the distribution of immune function and cytokine among the five TCM syndromes (P > 0.05), but there was statistically significant difference in the distribution of blood routine, liver and kidney function, and tumor biomarkers (P < 0.05). Conclusion: LKYDS, SDS, LKYDS-SDS, SDQSS, and DHS were the first five TCM syndromes in CRC. There were the significant correlations between the distribution of TCM syndrome and the clinical laboratory indicators, and the distribution of TCM syndromes was affected by surgery, radiotherapy, and chemotherapy.


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