| REVIEW ARTICLE |
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| Year : 2020 | Volume
: 6
| Issue : 4 | Page : 363-369 |
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The effect of hormones of the hypothalamic-pituitary-target gland axes in a kidney-yang deficiency syndrome model
Agra Darmawati Ayu1, Wen Pan1, Zou-Qin Huang2, Ling Zhao1
1 Teaching and Research Department of Meridians and Acupoints, School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2 Department of Acupuncture, Shanghai Pudong New District Hospital of Traditional Chinese Medicine, Shanghai, China
Correspondence Address:
Prof. Ling Zhao
School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai 201203
China
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/wjtcm.wjtcm_38_20
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Kidney-yang deficiency syndrome (KYDS) is a diagnostic pattern in the traditional Chinese medicine. Studies have shown that KYDS is related to the functional disorder of hormones of the hypothalamic-pituitary-target gland axes. The standard procedure used to mimic KYDS is the injection of a high dose of exogenous glucocorticoid (hydrocortisone and corticosterone). Such a model showed symptoms such as exhaustion, body twists, cold limbs, lying crowded together, decreased rectal temperature, sexual dysfunction, decreased reaction speed, reduced spontaneous activity, hair loss, loss of appetite, and weight loss. Moreover, the model manifested an imbalance in mutual control among the hormones of the pituitary-target gland axes, including adrenocorticotrophic hormone, CORT, CRH, thyroid-stimulating hormone, triiodothyronine, thyroxine, T, E2, follicle-stimulating hormone, luteinizing hormone, and 17-OHCS.
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