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Tocolysis effects of traditional Chinese medicine and their effective components
Tong-Hua Zhang1, Jian-Xin Liang2, Deng-Lu Long3, Min Ma4, Li-Guo Chen4, Da-Xiang Lu5, Xiao-Hua Jiang6, Xue-Song Yang7, Guang Wang8
1 Division of Histology & and Embryology, International Joint Laboratory for Embryonic Development & and Prenatal Medicine, Medical College; Department of Traditional Chinese and Western Medicine, Chinese Medicine College, Jinan University, Guangzhou 510632, China
2 Division of Histology & and Embryology, International Joint Laboratory for Embryonic Development & and Prenatal Medicine, Medical College; Department of Traditional Chinese and Western Medicine, Chinese Medicine College, Jinan University, Guangzhou 510632, China; Key Laboratory for Regenerative Medicine of The Ministry of Education of China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
3 Division of Histology & and Embryology, International Joint Laboratory for Embryonic Development & and Prenatal Medicine, Medical College, Jinan University, Guangzhou 510632, China
4 Department of Traditional Chinese and Western Medicine, Chinese Medicine College, Jinan University, Guangzhou 510632, China
5 Department of Pathophysiology, Institute of Brain Science Research, Key Laboratory of State Administration of Traditional Chinese Medicine of the People's People's Republic of China, School of Medicine, Jinan University, Guangzhou, 510632, China
6 Key Laboratory for Regenerative Medicine of The Ministry of Education of China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
7 Division of Histology & and Embryology, International Joint Laboratory for Embryonic Development & and Prenatal Medicine, Medical College; Key Laboratory for Regenerative Medicine of the Ministry of Education, Jinan University, Guangzhou 510632, China
8 Division of Histology & and Embryology, International Joint Laboratory for Embryonic Development & and Prenatal Medicine, Medical College; Department of Traditional Chinese and Western Medicine, Chinese Medicine College; Key Laboratory for Regenerative Medicine of the Ministry of Education, Jinan University, Guangzhou 510632, China
Correspondence Address:
Guang Wang,
Division of Histology and Embryology, International Joint Laboratory for Embryonic Development and Prenatal Medicine, Medical College, Jinan University, Guangzhou 510632
China
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/wjtcm.wjtcm_30_21
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Traditional Chinese medicine (TCM) for anti-abortion is based on the theory of gynecology of TCM, which aims to prevent and treat abdominal pain during pregnancy, fetal leakage, uneasy fetal movement, and fetal atrophy. Because of the complexity of the ingredients of Chinese Materia Medica, and the imprecise intervention mechanism for tocolysis, further investigation about the effects of Chinese herbs and their components on tocolysis by utilizing advanced technologies is required to be made. All the information available about TCM and its effects on pregnant women and fetuses was collected via electronic search using Web of Science, PubMed, and CNKI, and a library search was performed to locate classic herbal medicine books. The active ingredients in TCM were screened with the help of Traditional chinese medicine systems pharmacology database and analysis platform (TCMSP). The keywords being used included herbal names, pharmacology, pregnancy, threatened abortion, and fetus. Modern pharmacological studies have shown that TCM mainly prevents threatened abortion by a direct effect on the pregnant woman's immune system, sex hormones such as estrogen and progesterone, the uterus and the endometrium, and the decidual tissue such as the placenta. It may also address pregnancy complications due to advanced maternal age, infection, polycystic ovary syndrome, diabetes, and mental disorders caused by threat of a miscarriage. TCM protects against spontaneous miscarriage, but its mechanisms are largely unknown. This research applies scientific methods to characterize and examine the effective components of TCM and their application to lower the risk of abortion to the pregnant women and fetuses.
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